Lymphoma CDX Models

Explore Lymphoma CDX Models:

Moden NameDescription
SU-DHL-2Derived from human diffuse large B-cell lymphoma (DLBCL), ABC subtype; BCL2 rearranged, MYC-negative; used for BCL2-targeted therapy studies.
SU-DHL-4Germinal center B-cell (GCB) subtype DLBCL; BCL6-positive, TP53 mutant, CD20-positive; responsive to rituximab and chemotherapeutics.
SU-DHL-6GCB-DLBCL line with high BCL2 expression; TP53 wild-type; used for venetoclax sensitivity testing and apoptosis pathway analysis.
SU-DHL-10Derived from GCB-DLBCL; BCL6 rearranged, CD20-positive; used to test CD20-targeted and chemotherapy combination strategies.
Maver-1Mantle cell lymphoma (MCL) with t(11;14)(q13;q32) CCND1 overexpression; resistant to BTK inhibitors; used in studies of MCL drug resistance.
MinoMCL model with CCND1 overexpression; exhibits sensitivity to BTK and BCL2 inhibitors; used in combination therapy evaluation.
NAMALWABurkitt lymphoma model with MYC translocation and high CD20 expression; used for rituximab efficacy studies and lymphoma immunotherapy.
WSU-DLCL2DLBCL model expressing BCL2 and CD20; used in preclinical studies of anti-CD20 monoclonal antibodies and apoptosis modulators.
Z-138MCL line with t(11;14) translocation, CCND1 overexpression, ATM mutation; used in studies of DNA damage response inhibitors.
U937Human histiocytic lymphoma/monocytic leukemia; TP53 mutant, HLA-DR-positive; widely used to study differentiation and cytokine signaling.
FarageDLBCL of GCB subtype; EBV-negative, CD20-positive; used in antibody-based immunotherapy and lymphoma resistance models.
PfeifferGCB-DLBCL with MYC overexpression, CD20-positive; commonly used to evaluate rituximab-based combination treatments.
REC-1MCL with t(11;14) and high CCND1; BTK inhibitor-sensitive; used in studies of MCL signaling and drug resistance.
ToledoGCB-DLBCL model; BCL2-high, CD20-positive, TP53 mutant; used for venetoclax and anti-CD20 therapeutic evaluations.
HuT78Cutaneous T-cell lymphoma (Sézary syndrome); CD4-positive, TP53 mutant; used for studying T-cell lymphomas and HDAC inhibitors.
JeKo-1MCL model with t(11;14), overexpressing cyclin D1; BTK inhibitor-sensitive; used to test novel MCL combination therapies.
CCRF-SBDerived from B-cell acute lymphoblastic leukemia (B-ALL); used to evaluate glucocorticoid resistance and leukemic stem cell biology.
SU-DHL-1Anaplastic large cell lymphoma (ALCL) model; ALK-positive, CD30-positive; used for ALK inhibitor and immunotherapy testing.
OCI-LY3Activated B-cell-like DLBCL; MYD88 L265P mutation, NF-κB pathway activation; used in IKK and BTK pathway inhibitor studies.
HBL-1ABC-DLBCL with MYD88 L265P mutation and high BCL2 expression; standard model for BTK and IRAK4 inhibitor testing.
OCI-LY7GCB-DLBCL; TP53 wild-type, CD20-positive; used for chemotherapy sensitivity testing and BCR signaling analysis.
HHCutaneous T-cell lymphoma model; CD4+, CD30+; used for preclinical testing of HDAC inhibitors and immune checkpoint therapies.
H9T-cell lymphoma line; CD4+, CD3+; used in studies of T-cell malignancies and cytokine signaling inhibitors.
KARPAS-422GCB-DLBCL; BCL2 and EZH2 mutant, CD20-positive; used for epigenetic drug screening and anti-CD20 therapies.
SUPT1T-lymphoblastic lymphoma model; CD4+, CD8+, p53 wild-type; used in studies of retroviral infections and leukemia biology.