| Model Name | Description |
| SK-MEL-24 | Derived from human cutaneous melanoma; BRAF wild-type, NRAS mutant (Q61R); used in MEK inhibitor and MAPK pathway studies. |
| COLO 829 | Human melanoma line harboring BRAF V600E mutation; PTEN loss; a standard model for BRAF/MEK-targeted therapy development. |
| SK-MEL-5 | Melanoma model with BRAF V600E mutation and high HLA-A2 expression; used in immune checkpoint and T-cell targeting studies. |
| MDA-MB-435S | Originally classified as breast cancer, now recharacterized as melanoma; BRAF mutant, used in drug sensitivity and migration assays. |
| SK-MEL-3 | Cutaneous melanoma line with NRAS mutation; BRAF wild-type, TP53 mutant; used to study MAPK signaling and MEK inhibitor response. |
| MP41 | Uveal melanoma model with GNA11 mutation; BAP1 wild-type; used to investigate metastasis and therapies for uveal melanoma subtypes. |