XC7004 Cervical Cancer PDX Model

Model Information:

n/a

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Summary:

CategoryParameterModel Detail (XC7004)
IdentityModel IDXC7004
Cancer TypeCervical Cancer
Model TypePDX (Patient-Derived Xenograft)
Clinical BackgroundPatient Age47
Patient GenderFemale
EthnicityN/A
DiagnosisInvasive Squamous Cell Carcinoma (Keratinizing)
Subtype / Receptor StatusSCC (Squamous Cell Carcinoma)
StageFIGO Stage IIB (Parametrial invasion without pelvic wall extension)
Sample SiteCervix Uteri (Primary Resection)
Genomics & BiomarkersPrimary DriverHigh-Risk HPV-16 Positive / PIK3CA Mutation / FAT1 Loss
CytogeneticsN/A
WES (Whole Exome)N/A
RNA-SeqN/A
CNV ProfileN/A
Mutational LoadN/A
CharacterizationSurface Markersp16 (Strong/Diffuse+), p40+, p63+, CK5/6+, Ki-67 (High, ~55%)
Host StrainNSG (NOD scid gamma)
Inoculation RouteOrthotopic / Subcutaneous
Growth KineticN/A
PharmacologySoC ResponseN/A
Immune ProfilingN/A
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Growth Characteristics:

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