XB6010 Breast Cancer PDX Model

Model Information:

n/a

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Summary:

CategoryParameterModel Detail (XB6010)
IdentityModel IDXB6010
Cancer TypeBreast Cancer
Model TypePDX (Patient-Derived Xenograft)
Clinical BackgroundPatient Age61
Patient GenderFemale
EthnicityN/A
DiagnosisInvasive Carcinoma with Undifferentiated/Metaplastic Features
Subtype / Receptor StatusNA (Undetermined / Multiphenotypic)
StageStage IV (pT3 N1 M1 – Distant Metastasis)
Sample SiteMetastatic Pleural Effusion / Nodular Mass
Genomics & BiomarkersPrimary DriverTP53 Mutation / PIK3CA Alteration Complex
CytogeneticsComplex Karyotype
WES (Whole Exome)N/A
RNA-SeqN/A
CNV ProfileN/A
Mutational LoadN/A
CharacterizationSurface MarkersVimentin+, GATA3 (Weak/Focal), CK8/18 (Variable), Ki-67 (Very High, ~85%)
Host StrainNSG (NOD scid gamma)
Inoculation RouteOrthotopic (Mammary Fat Pad) / Subcutaneous
Growth KineticN/A
PharmacologySoC ResponseN/A
Immune ProfilingN/A
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Growth Characteristics:

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