XB6007 Breast Cancer PDX Model

Model Information:

n/a

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Summary:

CategoryParameterModel Detail (XB6007)
IdentityModel IDXB6007
Cancer TypeBreast Cancer
Model TypePDX (Patient-Derived Xenograft)
Clinical BackgroundPatient Age60
Patient GenderFemale
EthnicityN/A
DiagnosisInvasive Ductal Carcinoma (IDC)
Subtype / Receptor StatusER(3+), PR(3+), HER2(-)
StageStage IIA (pT2 N0 M0)
Sample SitePrimary Breast Tumor
Genomics & BiomarkersPrimary DriverPIK3CA Mutation / AKT1 Mutation
CytogeneticsN/A
WES (Whole Exome)N/A
RNA-SeqN/A
CNV ProfileN/A
Mutational LoadN/A
CharacterizationSurface MarkersER (Strongly+), PR (Strongly+), GATA3+, E-cadherin+, Ki-67 (Low-to-Moderate, ~15%)
Host StrainNSG (Requires 17β-estradiol supplementation)
Inoculation RouteOrthotopic (Mammary Fat Pad)
Growth KineticN/A
PharmacologySoC ResponseN/A
Immune ProfilingN/A
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Growth Characteristics:

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