XB6001 Breast Cancer PDX Model

Model Information:

n/a

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Summary:

CategoryParameterModel Detail (XB6001)
IdentityModel IDXB6001
Cancer TypeBreast Cancer
Model TypePDX (Patient-Derived Xenograft)
Clinical BackgroundPatient Age54
Patient GenderFemale
EthnicityN/A
DiagnosisInvasive Ductal Carcinoma (IDC)
Subtype / Receptor StatusTriple-Negative (ER-, PR-, HER2-)
StageStage IIIA (pT2 N2 M0)
Sample SitePrimary Breast Tumor (Mastectomy)
Genomics & BiomarkersPrimary DriverTP53 Mutation / PTEN Loss
CytogeneticsN/A
WES (Whole Exome)N/A
RNA-SeqN/A
CNV ProfileN/A
Mutational LoadN/A
CharacterizationSurface MarkersEGFR+, CK5/6+, E-cadherin+, Ki-67 (High, ~65%)
Host StrainNSG (NOD scid gamma)
Inoculation RouteOrthotopic (Mammary Fat Pad) / Subcutaneous
Growth KineticN/A
PharmacologySoC ResponseN/A
Immune ProfilingN/A
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Growth Characteristics:

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