XB4011 Bladder Cancer PDX Model

Model Information:

Metastatic transitional cell carcinoma of the bladder with high tumor burden in examined sections and malignant cells present in cytologic preparations.

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Summary:

CategoryParameterModel Detail (XB4011)
IdentityModel IDXB4011
Cancer TypeBladder Cancer
Model TypePDX (Patient-Derived Xenograft)
Clinical BackgroundPatient Age64
Patient GenderMale
EthnicityN/A
DiagnosisMetastatic Transitional Cell Carcinoma
StageStage IV / High Tumor Burden
Sample SiteMetastatic Site (Consistent with positive cytology)
Genomics & BiomarkersPrimary DriverTP53 / PIK3CA / HRAS
CytogeneticsN/A
WES (Whole Exome)N/A
RNA-SeqN/A
CNV ProfileN/A
Mutational LoadN/A
CharacterizationSurface MarkersGATA3+, CK7+, CK20+, High Ki-67
Host StrainNSG (NOD scid gamma)
Inoculation RouteSubcutaneous
Growth KineticN/A
PharmacologySoC ResponseN/A
Immune ProfilingN/A
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Growth Characteristics:

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