XB4010 Bladder Cancer PDX Model

Model Information:

Transitional cell carcinoma of the bladder with extensive tumor involvement of the sampled tissue and malignant cells identified in cytologic material.

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Summary:

CategoryParameterModel Detail (XB4010)
IdentityModel IDXB4010
Cancer TypeBladder Cancer
Model TypePDX (Patient-Derived Xenograft)
Clinical BackgroundPatient Age71
Patient GenderFemale
EthnicityN/A
DiagnosisTransitional Cell Carcinoma (Urothelial Carcinoma)
StageHigh-grade / Extensive Involvement
Sample SiteBladder Tissue / Cytologic Material
Genomics & BiomarkersPrimary DriverFGFR3 / TERT Promoter
CytogeneticsN/A
WES (Whole Exome)N/A
RNA-SeqN/A
CNV ProfileN/A
Mutational LoadN/A
CharacterizationSurface MarkersGATA3+, CK7+, CK20+, p63+
Host StrainNSG (NOD scid gamma)
Inoculation RouteSubcutaneous
Growth KineticN/A
PharmacologySoC ResponseN/A
Immune ProfilingN/A
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Growth Characteristics:

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