Ovarian Cancer CDX Models

Explore Ovarian Cancer CDX Models:

Model NameDescription
A2780Derived from human ovarian endometrioid adenocarcinoma; TP53 wild-type, cisplatin-sensitive; commonly used for chemotherapy and resistance studies.
ES-2Clear cell ovarian carcinoma model; TP53 mutant, PTEN-null; known for aggressive growth and used in studies of chemoresistance.
OV90High-grade serous ovarian carcinoma; TP53 mutant, BRCA1 wild-type; used in platinum-based and PARP inhibitor testing.
TOV112DEndometrioid ovarian carcinoma; PTEN mutant, TP53 wild-type; used to evaluate PI3K/AKT/mTOR inhibitors and hormonal therapy response.
PA-1Ovarian teratocarcinoma with wild-type TP53; used for studying differentiation, tumor heterogeneity, and chemoresistance.
CAOV3High-grade serous ovarian carcinoma; TP53 mutant, BRCA1 wild-type; moderately responsive to platinum and taxane therapies, used for drug development.