| Model Name | Description |
| KMS-28BM | Derived from bone marrow of a multiple myeloma patient; exhibits t(11;14)(q13;q32) CCND1 overexpression; used in studies of cell cycle and proteasome inhibitors. |
| KMS-11 | Multiple myeloma line with t(4;14)(p16;q32) translocation, FGFR3 and MMSET overexpression; sensitive to FGFR inhibitors and proteasome inhibitors. |
| MOLP-8 | Carries t(11;14) translocation with high CCND1 expression; BCL2-high, making it a strong model for venetoclax sensitivity testing. |
| RPMI 8226 | Classic multiple myeloma model; lacks common translocations, but expresses high CD38 and CD138; widely used to evaluate proteasome and IMiD therapies. |
| MM.1S | Glucocorticoid-sensitive myeloma line with wild-type NR3C1 (glucocorticoid receptor); used to study steroid-based and combination therapies. |
| MM.1R | Isogenic counterpart to MM.1S but glucocorticoid-resistant; contains mutated NR3C1; used to investigate mechanisms of steroid resistance in myeloma. |